Our Work

paper-scaffold is a Typst manuscript scaffold in which every number in the prose is read by id from a declaration file written by the analysis, with a checksum, a record of the code and data behind it…

paper-scaffold is a Typst manuscript scaffold in which every number in the prose is read by id from a declaration file written by the analysis, with a checksum, a record of the code and data behind it, and guards on what the prose assumes about it. A static gate reports stale figures, tables and builds without re-running the analysis, and checks prose rules, word limits and journal profiles. Word export goes through pandoc with native equations. An edit guard lets a wording pass drop a number but never invent one, and a set of packaged agent skills audits claims and methods against the code that computes them.

BigBed v0.1.0 The initial release of code lifted from GenomicFeatures.jl v1.0.0.

Recent work in quantum gravity has revealed that closed universes appear to admit only a one-dimensional Hilbert space, implying zero information content. The leading resolution by Harlow, Usatyuk, an…

Recent work in quantum gravity has revealed that closed universes appear to admit only a one-dimensional Hilbert space, implying zero information content. The leading resolution by Harlow, Usatyuk, and Zhao (arXiv:2501.02359, January 2025), featured in Quanta Magazine (November 2025), introduces observers as external additions to restore complexity. We demonstrate that this approach is self-contradictory: it resolves a closed universe problem by opening the universe, introducing boundaries in a system defined by their absence. We present a fundamentally different resolution. By proving that the open/closed distinction is itself a declaration and establishing observer-universe equivalence (O ≡ U), we derive the Totality Theorem: T = O + U = 1. The one-state result is not a paradox but a correct description of completeness: Shannon entropy H = 0 indicates full knowledge, not emptiness. We show that dimensionality itself is an artifact of partition, not a feature of reality. From three relations alone — T = 1, O ≡ U, dO = −dU — and a single structural principle (the Law of Identity A = A generates the binary partition A + ¬A = 1 with unique fixed point A = ¬A = 0.5), we resolve problems across every foundational domain: the unification of the four laws of thermodynamics as facets of a single identity, the black hole information paradox, the cosmological constant discrepancy, the Collatz and twin prime conjectures, Wigner's 67-year mystery of mathematical effectiveness, and the dissolution of Gödel's incompleteness as a property of notation rather than truth. All results derive from A = A.

Ushbu tadqiqotda bachadon miomasining turli topik variantlari mavjud reproduktiv yoshdagi ayollarda endometriyning exografik xususiyatlari qiyosiy baholandi. Tadqiqotga FIGO tasnifi bo'yicha submukoz …

Ushbu tadqiqotda bachadon miomasining turli topik variantlari mavjud reproduktiv yoshdagi ayollarda endometriyning exografik xususiyatlari qiyosiy baholandi. Tadqiqotga FIGO tasnifi bo'yicha submukoz (FIGO 0–2), intramural va intramural-subseroz (FIGO 3–5), hamda subseroz (FIGO 6–7) miomasi mavjud 120 nafar ayol va 30 nafar shartli sog'lom ayol jalb qilindi. Exografik tekshiruv davomida endometriy qalinligi, uning "uch chiziqli" strukturasi, bachadon bo'shlig'i deformatsiyasi, endometriy qalinligi asimmetriyasi, bazal qatlam holati, endometriy–miometriy chegara sohasining aniqligi va lokal yupqalashish belgilari tahlil qilindi. Natijalar FIGO 0–2 submukoz miomalarda bachadon bo'shlig'i deformatsiyasi va bazal qatlam o'zgarishlari, FIGO 3–5 intramural miomalarda esa endometriy– miometriy chegara sohasining noaniqligi va endometriyning lokal yupqalashishi ko'proq uchrashini ko'rsatdi. FIGO 6–7 subseroz miomalarda endometriyga bevosita ta'sir belgilari nisbatan kam kuzatildi. Olingan ma'lumotlar bachadon miomasining topik joylashuvi endometriyning morfofunksional holatiga sezilarli ta'sir ko'rsatishini tasdiqlaydi. Exografik baholash mioma bilan bog'liq endometriy o'zgarishlarini erta aniqlash va davolash taktikasini individuallashtirishda muhim noinvaziv diagnostik usul hisoblanadi.

This research compendium supports a national ecological time-series study of health-system capacity, infant mortality, and life expectancy in Türkiye from 1967 to 2024. It contains the final anal…

This research compendium supports a national ecological time-series study of health-system capacity, infant mortality, and life expectancy in Türkiye from 1967 to 2024. It contains the final analytic dataset, source documentation, recovered R analysis scripts, model objects, final tables, diagnostics, measurement-break sensitivity analyses, and publication figures. The analysis separates descriptive structural change and post-2003 trajectories from diagnostically admissible long-run relationships and stationary annual associations. This archive accompanies the manuscript “Health-System Capacity and Population Health: Long-Run Evidence from Türkiye, 1967–2024”.

Abstract: This Author has worked with migrant construction workers throughout his long career and has witnessed a variety of problems they face. The outcomes of earlier studies also supported his expe…

Abstract: This Author has worked with migrant construction workers throughout his long career and has witnessed a variety of problems they face. The outcomes of earlier studies also supported his experience. Hence, after superannuation, he was compelled to study their situation in detail and continued his research on migrant construction workers. Before commencing fieldwork, he conducted observational (Covert and naturalist) research at Labour Chowk, Greater Noida, UP, as a preliminary study. It is felt that there is a need for a systematic sociological analysis of the situation and for its presentation to policymakers. Furthermore, this will serve as an additional input to the research study on migrant construction workers. The problems faced by migrant construction workers in general constitute a 21st-century crisis with social relevance and require the attention of all concerned. The methodology employed is covert and naturalistic observational research. Based on observations, their interpretation, and analysis, the author reached certain conclusions. As this is an informal, disorganised, temporary arrangement, there is no proper infrastructure, such as toilets, drinking water, or a closed shed for protection during the hot summer and on rainy days. There is no guaranteed minimum wage or minimum working hours, and workers are subject to employers' discretion. Semi-skilled workers, such as painters and masons, have a strong likelihood of selection and skill development, and their skills are in demand. The author also recommends that the current mechanism be formalised as a physical platform to address these problems.

Воспалительные процессы органов женской репродуктивной системы имеют не только клиническое, но и выраженное психосоматическое значение. При частом и рецидивирующем течении боль, зуд, жжение, патологич…

Воспалительные процессы органов женской репродуктивной системы имеют не только клиническое, но и выраженное психосоматическое значение. При частом и рецидивирующем течении боль, зуд, жжение, патологические выделения, неприятный запах и диспареуния способны поддерживать хронический стресс, тревогу, нарушения сна, снижение самооценки и ограничение социальной и сексуальной активности. Наиболее убедительные данные о снижении качества жизни получены при рецидивирующем вульвовагинальном кандидозе, бактериальном вагинозе, воспалительных заболеваниях органов малого таза и хронической тазовой боли. В исследованиях с применением «SF-36», «WHOQOL-BREF» и «EQ-5D» выявляется ухудшение физических, психических и социальных доменов, а сексуальная функция страдает вследствие боли, ожидания рецидива и изменения интимного поведения [2-7, 12-14]. Цель статьи - систематизировать современные данные о роли воспалительных процессов репродуктивной системы в формировании психосоматических нарушений у женщин, показать взаимосвязь рецидивов с качеством жизни, психическим состоянием и сексуальным здоровьем и обосновать необходимость пациент-ориентированной модели помощи. Проведён аналитический обзор 30 ключевых публикаций, включая клинические рекомендации, систематические обзоры, когортные и поперечные исследования. Синтез доказательств показывает, что повторяемость воспалительных эпизодов и хроническая тазовая боль являются факторами накопленного бремени заболевания; особенно уязвимыми доменами являются психическое здоровье, социальное функционирование, сексуальная функция и субъективная оценка общего здоровья. Практическое значение имеет включение валидированных опросников качества жизни и сексуальной функции в комплексное наблюдение пациенток.

Воспалительные процессы органов женской репродуктивной системы имеют не только клиническое, но и выраженное психосоматическое значение. При частом и рецидивирующем течении боль, зуд, жжение, патологич…

Воспалительные процессы органов женской репродуктивной системы имеют не только клиническое, но и выраженное психосоматическое значение. При частом и рецидивирующем течении боль, зуд, жжение, патологические выделения, неприятный запах и диспареуния способны поддерживать хронический стресс, тревогу, нарушения сна, снижение самооценки и ограничение социальной и сексуальной активности. Наиболее убедительные данные о снижении качества жизни получены при рецидивирующем вульвовагинальном кандидозе, бактериальном вагинозе, воспалительных заболеваниях органов малого таза и хронической тазовой боли. В исследованиях с применением «SF-36», «WHOQOL-BREF» и «EQ-5D» выявляется ухудшение физических, психических и социальных доменов, а сексуальная функция страдает вследствие боли, ожидания рецидива и изменения интимного поведения [2-7, 12-14]. Цель статьи - систематизировать современные данные о роли воспалительных процессов репродуктивной системы в формировании психосоматических нарушений у женщин, показать взаимосвязь рецидивов с качеством жизни, психическим состоянием и сексуальным здоровьем и обосновать необходимость пациент-ориентированной модели помощи. Проведён аналитический обзор 30 ключевых публикаций, включая клинические рекомендации, систематические обзоры, когортные и поперечные исследования. Синтез доказательств показывает, что повторяемость воспалительных эпизодов и хроническая тазовая боль являются факторами накопленного бремени заболевания; особенно уязвимыми доменами являются психическое здоровье, социальное функционирование, сексуальная функция и субъективная оценка общего здоровья. Практическое значение имеет включение валидированных опросников качества жизни и сексуальной функции в комплексное наблюдение пациенток.

Official version of the quarto and data source code

Previously known as polycystic ovarian syndrome (PCOS), polyendocrine metabolic ovarian syndrome (PMOS) is a common endocrine and metabolic condition linked to insulin resistance, abnormal lipid metab…

Previously known as polycystic ovarian syndrome (PCOS), polyendocrine metabolic ovarian syndrome (PMOS) is a common endocrine and metabolic condition linked to insulin resistance, abnormal lipid metabolism, irregular or missing ovulation, and increased androgen production. PMOS is increasingly recognized as a more comprehensive systemic syndrome that may have long-term impacts on metabolic health and cancer risk, despite the fact that it was once primarily thought of as a reproductive disorder. The association with ovarian and breast cancers is still unclear, but the strongest and most reliable evidence has been documented for endometrial cancer. The potential link between PMOS and cancer may be explained by a number of biological processes. Without enough progesterone, persistent anovulation can expose the endometrium to estrogen for extended periods of time, which could promote ongoing endometrial development. Through the insulin/IGF system and signaling pathways like PI3K/Akt/mTOR and MAPK/ERK, insulin resistance and increased insulin levels can also stimulate cell growth. Abnormal cellular activity may also be caused by other factors, including as excess androgens, oxidative stress, chronic inflammation, genetic and epigenetic alterations, and disruptions in the gut flora. However, as obesity, diabetes, infertility, and reproductive variables can all influence cancer risk, these processes by themselves do not prove that PMOS causes cancer. Therefore, more study is required to elucidate these relationships, find trustworthy biomarkers, and develop practical methods for early risk assessment and cancer prevention in women with PMOS.